Journal of Kermanshah University of Medical Sciences

Published by: Kowsar

In Silico and in Vitro Studies of Cytotoxic Activity of Different Peptides Derived from Human Lactoferrin Protein

Mahnoosh Fatemi 1 , Fereshte Ghandehari 2 , * , Somaye Bahrami 2 and Nahid Tajedin 1
Authors Information
1 Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, IR Iran
2 Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, IR Iran
Article information
  • Journal of Kermanshah University of Medical Sciences: March 2018, 22 (1); e69544
  • Published Online: March 30, 2018
  • Article Type: Research Article
  • Received: September 17, 2017
  • Accepted: March 6, 2018
  • DOI: 10.5812/jkums.69544

To Cite: Fatemi M, Ghandehari F, Bahrami S, Tajedin N. In Silico and in Vitro Studies of Cytotoxic Activity of Different Peptides Derived from Human Lactoferrin Protein, J Kermanshah Univ Med Sci. 2018 ; 22(1):e69544. doi: 10.5812/jkums.69544.

Abstract
Copyright © 2018, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
Acknowledgements
References
  • 1. Hancock RE, Diamond G. The role of cationic antimicrobial peptides in innate host defences. Trends Microbiol. 2000;8(9):402-10. [PubMed: 10989307].
  • 2. Rodrigues L, Teixeira J, Schmitt F, Paulsson M, Mansson HL. Lactoferrin and cancer disease prevention. Crit Rev Food Sci Nutr. 2009;49(3):203-17. doi: 10.1080/10408390701856157. [PubMed: 19093266].
  • 3. Sharma A, Kapoor P, Gautam A, Chaudhary K, Kumar R, Chauhan JS, et al. Computational approach for designing tumor homing peptides. Sci Rep. 2013;3:1607. doi: 10.1038/srep01607. [PubMed: 23558316]. [PubMed Central: PMC3617442].
  • 4. Ory DS, Neugeboren BA, Mulligan RC. A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc Natl Acad Sci U S A. 1996;93(21):11400-6. [PubMed: 8876147]. [PubMed Central: PMC38069].
  • 5. Qiao J, Moreno J, Sanchez-Perez L, Kottke T, Thompson J, Caruso M, et al. VSV-G pseudotyped, MuLV-based, semi-replication-competent retrovirus for cancer treatment. Gene Ther. 2006;13(20):1457.
  • 6. Tyagi A, Kapoor P, Kumar R, Chaudhary K, Gautam A, Raghava GP. In silico models for designing and discovering novel anticancer peptides. Sci Rep. 2013;3:2984. doi: 10.1038/srep02984. [PubMed: 24136089].
  • 7. van Meerloo J, Kaspers GJ, Cloos J. Cell sensitivity assays: the MTT assay. Methods Mol Biol. 2011;731:237-45. doi: 10.1007/978-1-61779-080-5_20. [PubMed: 21516412].
  • 8. Gaspar D, Veiga AS, Castanho MA. From antimicrobial to anticancer peptides. A review. Front Microbiol. 2013;4:294. doi: 10.3389/fmicb.2013.00294. [PubMed: 24101917]. [PubMed Central: PMC3787199].
  • 9. Risso A, Braidot E, Sordano MC, Vianello A, Macri F, Skerlavaj B, et al. BMAP-28, an antibiotic peptide of innate immunity, induces cell death through opening of the mitochondrial permeability transition pore. Mol Cell Biol. 2002;22(6):1926-35. [PubMed: 11865069]. [PubMed Central: PMC135593].
  • 10. Suttmann H, Retz M, Paulsen F, Harder J, Zwergel U, Kamradt J, et al. Antimicrobial peptides of the Cecropin-family show potent antitumor activity against bladder cancer cells. BMC Urol. 2008;8:5. doi: 10.1186/1471-2490-8-5. [PubMed: 18315881]. [PubMed Central: PMC2276511].
  • 11. Lehmann J, Retz M, Sidhu SS, Suttmann H, Sell M, Paulsen F, et al. Antitumor activity of the antimicrobial peptide magainin II against bladder cancer cell lines. Eur Urol. 2006;50(1):141-7. doi: 10.1016/j.eururo.2005.12.043. [PubMed: 16476519].
  • 12. Hoskin DW, Ramamoorthy A. Studies on anticancer activities of antimicrobial peptides. Biochim Biophys Acta. 2008;1778(2):357-75. doi: 10.1016/j.bbamem.2007.11.008. [PubMed: 18078805]. [PubMed Central: PMC2238813].
  • 13. Ghandehari F, Behbahani M, Pourazar A, Noormohammadi Z. In silico and in vitro studies of cytotoxic activity of different peptides derived from vesicular stomatitis virus G protein. Iran J Basic Med Sci. 2015;18(1):47-52. [PubMed: 25810875]. [PubMed Central: PMC4366742].
  • 14. Zachowski A. Phospholipids in animal eukaryotic membranes: transverse asymmetry and movement. Biochem J. 1993;294 ( Pt 1):1-14. [PubMed: 8363559]. [PubMed Central: PMC1134557].
  • 15. Ma J, Guan R, Shen H, Lu F, Xiao C, Liu M, et al. Comparison of anticancer activity between lactoferrin nanoliposome and lactoferrin in Caco-2 cells in vitro. Food Chem Toxicol. 2013;59:72-7. doi: 10.1016/j.fct.2013.05.038. [PubMed: 23743119].
  • 16. Zhang Y, Lima CF, Rodrigues LR. Anticancer effects of lactoferrin: underlying mechanisms and future trends in cancer therapy. Nutr Rev. 2014;72(12):763-73. doi: 10.1111/nure.12155. [PubMed: 25406879].
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments