The effect of 6-week high intensity interval training on the VEGF/COL-18 ratio and some echocardiographic indices in rats with myocardial infarction

AUTHORS

Abbas Ali Gaeini 1 , Mohammad Reza Kordi 1 , Reza Nuri 2 , Pedram Ghorbani 2 , Sara Karbalaeifar 2 , *

AUTHORS INFORMATION

1 Dept. of Physical education, University of Tehran, Tehran, Iran

2 Dept. of Physical education, University of Tehran, Kish international campus, Kish, Iran

How to Cite: Gaeini A A, Kordi M R, Nuri R, Ghorbani P, Karbalaeifar S. The effect of 6-week high intensity interval training on the VEGF/COL-18 ratio and some echocardiographic indices in rats with myocardial infarction, J Kermanshah Univ Med Sci. 2016 ; 20(3):e69691. doi: 10.22110/jkums.v20i3.3292.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 20 (3); e69691
Published Online: December 19, 2016
Article Type: Original Article
Received: May 30, 2016
Accepted: November 10, 2016
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Abstract

Introduction: Myocardial infarction (MI) is the irreversible cell death caused by ischemia in parts of myocardium. The molecular process of increased capillary density in response to activity and its appropriate intensity is not clear yet. Therefore, this research aimed to evaluate the effect of 6-week high intensity interval training on the VEGF/COL-18 ratio and echocardiographic indices in rats with MI.

Methods: Twelve Wistar male rats of 10 weeks old and mean weight 250-300gr were allocated to two groups of experimental (60 minutes of interval treadmill running for four minutes with the intensity of 85-90 and two minutes of active rest at 50-60 percent of VO2max for four days a week for 6 weeks) and control group (without any training). Real-time PCR was used to assess the expression of VEGF and COL-18 genes after inducing MI, and shortening fractional and ejection fraction were investigated as echocardiographic indices. Data were analyzed in SPSS18 using independent t test (α≤ 0.05).

Results: The findings showed that there was no significant increase in the VEGF/COL-18 ratio in the HIIT group (1.856 mg/ml) as compared with the control group (1.245 mg/ml) (p=0.263). A significant increase was observed in the HIIT group for SF (77.461±7.022%) and EF (41.625±6.847%) as compared with the control group (64.483±3.695%) and (31.320±3.460%), respectively (p=0.001).

Conclusion: In general, 6 weeks of high intensity interval training can effectively increase angiogenesis factors and improve myocardial function in male Wistar rats after MI.

Keywords

angiogenesis myocardial infarction high intensity interval training

© 2016, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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