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The effect of allopurinol treatment regimen on serum uric acid and arterial blood pressure in hemodialysis patients

AUTHORS

Hamidreza Omrani 1 , Seyed Muhammad Kazem Sadeghi 1 , * , Dariush Raeisi 1 , Amirhosein Hashemian 2

AUTHORS INFORMATION

1 Department of Internal Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Research Center for Environmental Determinants of Health (RCEDH), Kermanshah University of Medical Sciences, Kermanshah, Iran

How to Cite: Omrani H, Sadeghi S M K, Raeisi D, Hashemian A. The effect of allopurinol treatment regimen on serum uric acid and arterial blood pressure in hemodialysis patients, J Kermanshah Univ Med Sci. 2016 ; 20(2):e69699. doi: 10.22110/jkums.v20i2.2839.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 20 (2); e69699
Published Online: September 19, 2016
Article Type: Original Article
Received: February 23, 2016
Accepted: June 25, 2016
DOI : 10.22110/jkums.v20i2.2839
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Abstract

Introduction: Controlling and reducing serum uric acid levels may have beneficial effects on blood pressure control. The current study was carried out to assess the effects of allopurinol administration on serum uric acid and arterial blood pressure among the patients under hemodialysis. 

Methods: This double-blind clinical trial was conducted on 132 hemodialysis patients (two separate groups) suffering from hyperuricemia and hypertension at Imam Reza hospital, Kermanshah in 2014. The first group received a daily dose of 100 mg allopurinol and the second group, as control, received placebo. The demographic data, vital signs, paraclinical data and comorbidities of all patients were recorded in a checklist. Serum uric acid and blood pressure were measured at the end of the first, second and third months. The obtained data were analyzed by SPSS software using t-test, paired t-test and repeated measure t-test.

Results: The results showed that allopurinol significantly reduced systolic and diastolic blood pressure and uric acid level in the patients with chronic renal dysfunction. This reduction was also reported to be significant between the patient and control groups at different times.  

Conclusion: Given the beneficial effect of allopurinol on the patients with chronic renal dysfunction, this drug can be used in this group of patients.

Keywords

Allopurinol serum uric acid arterial blood pressure hemodialysis

© 2016, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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