The effect of selenium on immunogenicity of influenza vaccine in the elderly: A case-control double-blinded clinical trial

AUTHORS

Alireza Janbakhsh 1 , * , Feizollah Mansouri 1 , Siavash Vaziri 1 , Babak Sayad 1 , Mandana Afsharian 1 , Mansour Rezaei 2 , Sohrab Heidari 1

AUTHORS INFORMATION

1 Department of Infectious Diseases, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Department of Biostatistics and Epidemiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

How to Cite: Janbakhsh A , Mansouri F, Vaziri S, Sayad B, Afsharian M, et al. The effect of selenium on immunogenicity of influenza vaccine in the elderly: A case-control double-blinded clinical trial , J Kermanshah Univ Med Sci. 2016 ; 20(1):e69746. doi: 10.22110/jkums.v20i1.3122.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 20 (1); e69746
Published Online: June 19, 2016
Article Type: Original Article
Received: May 09, 2016
Accepted: June 14, 2016
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Abstract

Introduction: Influenza can cause more severe diseases and higher rate of morbidity and mortality in the elderly population. Therefore, they should receive influenza vaccine annually. However, the host response to vaccine is less in older individuals. On the other hand, selenium can act as a stimulator of the immune system and cause increased immunity and response to vaccine. This study was carried out to determine the effect of selenium on antibody production against influenza vaccine. By verifying this effect, selenium can be recommended as an adjuvant therapy in the elderly.

Methods: A total of 110 subjects were selected at Infectious Diseases Research Center of Imam Reza Hospital in Kermanshah. They were divided into two groups of adjuvant (N=56) and placebo (N=54). The adjuvant group received influenza vaccine and selenium tablet. The placebo group received influenza vaccine and placebo tablet. Venous blood samples were taken before and four weeks after vaccination and the results were compared between the two groups.

Results: Seroconversion, seroprotection, and geometric mean titer (GMT) for three strains (H1N1, H3N2, and B) were assessed. The seroconversion and GMT rates against influenza B vaccine component were significantly higher in adjuvant group than placebo group.

Conclusion: Considering the ability of selenium in induction of a better response to influenza vaccine in older people as well as its low cost and accessibility, selenium can be used to increase antibody level in such cases.

Keywords

Influenza Vaccine Selenium Elderly Patients

© 2016, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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