Effect of crocin on reducing the number of embryos and implantation sites in mice

AUTHORS

Ali Pourmotabbed 1 , Seyed Ershad Nedaei 1 , * , Shirin Javidi Helan 1 , Cyrus Jalili 2 , Mozafar Khazaei 2

AUTHORS INFORMATION

1 Dept. of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 19 (5); e69828
Published Online: November 19, 2015
Article Type: Article Commentary
Received: June 22, 2015
Accepted: October 06, 2015
Crossmark

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background: Crocin is one of the main components of saffron. The effect of saffron on birth abortion has been established. So, the possible effect of crocin on abortion was evaluated in this study.

Methods: Pregnant mice were divided into 8 groups. Each group received crocin (0 or 10 or 50 or 100 mg/kg, i.p.) from the first to the fifth day of pregnancy. Then, the first four groups were sacrificed on the seventh day to evaluate the implantation sites. The other four groups were sacrificed on the 20th day and the number of embryos was counted. Data were analyzed by ANOVA.

Results: Administration of crocin (50 and 100 mg/kg) significantly reduced the mean number of implantation sites and embryos compared to the control group (P<0.05).

Conclusion: Administration of high doses of crocin in the first week of pregnancy reduced the number of implantation places and embryos in mice.

Keywords

Crocin implantation sites embryos mouse

© 2015, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
Fulltext

References
1 The references of this article is available on PDF
COMMENTS

LEAVE A COMMENT HERE: