Comparative study of the oxidative stress markers and antioxidant profile in patients with primary open-angle glaucoma and healthy subjects

AUTHORS

Gholamreza Shahsavari 1 , * , Asghar Mohammad pour Konani 2 , Arezoo Miraftabi 3

1 Department of Clinical Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran

2 Faculty of Medicine, Lorestan University of Medical Sciences. Khoramabad, Iran

3 Eye Research Center, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran

How to Cite: Shahsavari G, Mohammad pour Konani A, Miraftabi A. Comparative study of the oxidative stress markers and antioxidant profile in patients with primary open-angle glaucoma and healthy subjects, J Kermanshah Univ Med Sci. 2015 ; 19(3):e69875. doi: 10.22110/jkums.v19i3.2020.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 19 (3); e69875
Published Online: July 19, 2015
Article Type: Original Article
Received: January 31, 2015
Accepted: June 02, 2015
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Abstract

Background: Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness. The serum oxidant/antioxidant profile alteration has been reported in ocular pathologies. The aim of this study was to compare the oxidative stress markers and antioxidant profile in patients with primary open-angle glaucoma and healthy subjects.

Methods: This study was conducted on 84 POAG patients (40 women and 44 men) and 80 healthy subjects (43 women and 37 men) referring to department of ophthalmology at Hazrat Rasol hospital. In this study, the total plasma antioxidant capacity (TAC), malonyldialdehyde (MDA) concentration, erythrocyte glutathione (GLT) and advanced oxidation protein products (AOPP) were measured and compared.

Results: The serum levels of TAC in patients with POAG significantly decreased than those of the healthy subjects (p<0.001), while the MDA levels in these patients increased significantly (p<0.025). Also, the red blood cell glutathione  level in patients with POAG was significantly increased compared with healthy subjects (p<0.016).

Conclusion: Significant enhancement of lipid and protein oxidation and an remarkable reduction   of total antioxidant capacity in POAG patients  compared to healthy subjects may indicate the pathological role of rising oxidative damage in primary open-angle glaucoma.

Keywords

Primary open-angle glaucoma total antioxidant capacity oxidative stress

© 2015, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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