The combined effect of laser and oral administration of Iranian propolis extract on skin wound healing in male rats

AUTHORS

Nematollah Ghaibi 1 , Mohammad Sofiabadi 2 , * , Amir Farzam 3 , Mina Homayonizade 4 , Monireh Sadat Afzali Arani 4

AUTHORS INFORMATION

1 Biomedical Technology Development Center, Qazvin University of Medical Sciences, Qazvin, Iran

2

3 Dept. of Pathology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran

4 Dept. of Anesthesiology, School of Paramedical Sciences, Qazvin University of Medical Sciences, Qazvin, Iran

How to Cite: Ghaibi N, Sofiabadi M, Farzam A, Homayonizade M, Afzali Arani M S. The combined effect of laser and oral administration of Iranian propolis extract on skin wound healing in male rats, J Kermanshah Univ Med Sci. 2015 ; 19(2):e69886. doi: 10.22110/jkums.v19i2.2195.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 19 (2); e69886
Published Online: May 29, 2015
Article Type: Research Article
Received: November 24, 2014
Accepted: May 19, 2015
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Abstract

Background: To date, a lot of research has been carried out on the effect of medications and surgical methods on the treatment of wounds, but no ideal achievement has been obtained yet. This study was conducted to investigate the  single and combined effect of laser and propolis on skin wound healing in male rats.

Methods: 40 Wistar male rats (200-250 g) were divided into 4 groups (n= 10). All animals were anesthetized and sterile skin wound was created by surgical scissors.  Control group had no treatment, the second group was treated with laser (10 mW), the third group was treated with oral propolis (100 mg /kg; 3 times /day) and the forth group was treated with both laser and propolis. The wound healing level was measured based on the wound area and urinary hydroxyproline content.

Results: Urinary hydroxyproline content was increased in groups treated with laser, propolis and combined laser and propolis compared to the control group (P<0.01, 0.05 and 0.01, respectively). Also at the end of the treatment period, the wound extent was significantly lower in the laser, propolis, and combined laser and propolis groups than the control (P<0.05, 0.05 and 0.01, respectively). There was no significant difference between treatment groups.

Conclusion: Our results showed that oral administration of propolis or low power laser radiation can increase the wound healing rate.

Keywords

wound healing low power laser oral propolis extract

© 2015, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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