Antibacterial effect of bioactive glass nanoparticles prepared via sol gel method

AUTHORS

Zahra Nazemi 1 , Mehdi Mehdikhani-Nahrkhalaji 2 , * , Masoumeh Haghbin Nazarpak 3 , Hamid Staji 4

1 Faculty of Biotechnology, Semnan University, Semnan, Iran

2 Dept. of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran

3 New Technologies Research Center (NTRC), Amirkabir University of Technology, Tehran, Iran

4 Faculty of Veterinary Medicine, Semnan University, Semnan, Iran

How to Cite: Nazemi Z, Mehdikhani-Nahrkhalaji M, Haghbin Nazarpak M, Staji H. Antibacterial effect of bioactive glass nanoparticles prepared via sol gel method, J Kermanshah Univ Med Sci. 2014 ; 18(7):e74077. doi: 10.22110/jkums.v18i7.1869.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 18 (7); e74077
Published Online: October 29, 2014
Article Type: Original Article
Received: June 02, 2014
Accepted: September 30, 2014
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Abstract

Background: Infection constitutes the most important complication caused by biomaterials. Bioactive glasses have properties such as osteoconductivity and good restorability, some of which have revealed antibacterial effects. Therefore, these biomaterials are appropriate candidates for orthopedic and dental applications. The present study was conducted to analyze the antibacterial effect of bioactive glass nanoparticles.

Methods: In this experimental study, 37S and 58S glass compositions were synthesized via sol-gel technique. Characterization techniques such as X-ray diffraction (XRD), scanning electron microscopy (SEM) and X-ray fluorescent (XRF) were used for the prepared powders. The antibacterial activity of these compounds was studied using Escherichia coli as gram negative and Staphylococcus aureus as gram positive bacteria. The antibacterial effect of samples was evaluated at concentration of 25, 50 and 100 mg/ml.

Results: The particle size of the samples was mainly less than 100 nm. The 37S glass showed the highest antibacterial activity and the minimum bactericidal (MBC) at 25 mg/ml concentration against both bacteria. At broth concentrations below 100 mg/ml, 58S showed no antibacterial activity; however, it completely eliminated Escherichia bacteria and reduced the growth of Staphylococcus aureus bacteria.

Conclusion: These bioactive glass nanopowders can be regarded as good candidates in orthopedic application for the treatment of bone and dental defects but need supplementary and more evaluation considering their antibacterial effect on two important bacteria.

Keywords

antibacterial activity bioactive glass nanoparticles

© 2014, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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