Evaluation of N-Acetyl Cysteine performance in acetaminophen poisoning using certain liver and renal factors in plasma

AUTHORS

Armin Salek Maghsoudi 1 , Mohammad Reza Sattari 1 , * , Ali Ostadi 2 , Zeynab Mazloumi 1 , Mohammad Shokrzadeh 1

AUTHORS INFORMATION

1 Dept. of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

2 Dept. of Internal Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

How to Cite: Salek Maghsoudi A, Sattari M R, Ostadi A, Mazloumi Z, Shokrzadeh M. Evaluation of N-Acetyl Cysteine performance in acetaminophen poisoning using certain liver and renal factors in plasma, J Kermanshah Univ Med Sci. 2014 ; 18(7):e74078. doi: 10.22110/jkums.v18i7.1743.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 18 (7); e74078
Published Online: October 29, 2014
Article Type: Original Article
Received: May 12, 2014
Accepted: October 07, 2014
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Abstract

Background: Annually, acetaminophen poisoning causes probable acute liver and renal failures in different societies. N-acetyl cystein (NAC), first suggested as an effective antidote to fight against acetaminophen poisoning in 1970, prevents the binding of NAPQI to hepatic cells.

Methods: In the present study 30 patients with the average age of 27 and acetaminophen poisoning who referred to the poisons unit of Sina hospital in Tabriz were selected as the study sample. During the 24 hours of hospitalization, the blood samples of the patients were taken and collected in heparinized tubes.  The plasma was separated by centrifuge and kept in tubes in -70°C until it was analyzed by a high performance liquid chromatography method (HPLC) and laboratory analytical kits.

Results: the glutathione peroxidase (GPX) activity difference between the patients and control group was significant at first (P<0.05) but this significant difference disappeared following the treatment. A significant difference was observed in urea level after 24 hours of treatment between the patients and control group (P<0.05). However, at the beginning of the treatment and before administration of NAC, no significant difference was reported between the plasma levels of urea (P>0.05).

Conclusion: The activity level of GPX changed before a tangible change in regular liver enzymes. Urea level increased after 24 hours of treatment despite serum therapy and hydration condition.

Keywords

N-Acetyl cysteine acetaminophen urea alanine transaminase aspartate aminotransferase gluthalion peroxidase

© 2014, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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