Comparison of the effect of accelerated and classic vaccination schedules against Hepatitis B on the short-term production of protective antibody level: a meta-analysis study

AUTHORS

Behdad Pakseresht 1 , Siavash Vaziri 1 , Alireza Janbakhsh 1 , Babak Sayad 1 , Mandana Afsharian 1 , Fiezollah Mansouri 1 , Omid Beiki 2 , *

AUTHORS INFORMATION

1 Dept. of Infectious and Tropical Diseases, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Research Center for Environmental Determinants of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 18 (2); e74167
Published Online: May 29, 2014
Article Type: Research Article
Received: November 25, 2013
Accepted: April 22, 2014
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Abstract

Background: Hepatitis B is a common viral disease and one of the most common causes of cirrhosis and Hepatocellular Carcinoma (HCC). This disease is preventable via vaccination in most individuals. The aim of this study was to compare the accelerated and classic vaccination schedules against hepatitis B in the short-term production of protective antibody level. 

Methods: A couple of scientific internet resources were searched to find the relevant studies. The abstracts of 156 studies and full texts of some of them were reviewed and finally, 19 articles relevant to the objective of the study were selected.  From among the 19 articles remained, 11 articles with a score of 3 out of 5 (JADAD SCORE) were included as high quality studies.

Results: The antibody level of 10 mIU/ml or above was considered as positive vaccination response. According to the results of random effect model, no statistically significant difference was reported between the accelerated and conventional vaccination methods in terms of serum protection  (OR=0653, CI: 0.425-1.004). However, it seems that the accelerated method is less strong. 

Conclusion: Although it seems accelerated vaccination method has less power, the difference has been trivial in most of the studies. Accelerated vaccination is recommended in situations where faster protective antibody level is needed.

Keywords

Hepatitis B conventional vaccination method accelerated vaccination method meta-analysis

© 2014, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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