Effects of simultaneous Formaldehyde vapor and noise exposure on pituitary-gonadal axis in adult male mice

AUTHORS

Shahram Vosoughi 1 , Hassan Asilian Mahabadi 2 , * , Ali Khavanin 2 , Mojdeh Salehnia 3 , Abdolhossein Shahverdi 4 , Vahid Esmaeili 4 , Ardalan Soleimanian 2

AUTHORS INFORMATION

1 Dept. of Health Sciences, School of Health, Safety and Environment, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Dept. of Occupational and Environmental Health, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran

3 Dept. of Anatomical Sciences, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran

4 Embryology Department, Reproductive Biomedicine Research Center, Royan Institute, ACECR, Tehran, Iran

How to Cite: Vosoughi S, Asilian Mahabadi H, Khavanin A, Salehnia M, Shahverdi A, et al. Effects of simultaneous Formaldehyde vapor and noise exposure on pituitary-gonadal axis in adult male mice, J Kermanshah Univ Med Sci. 2013 ; 16(8):e77270.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 16 (8); e77270
Published Online: March 29, 2013
Article Type: Research Article
Received: April 10, 2012
Accepted: July 24, 2012

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Abstract

Background: Formaldehyde (H2C = O), is a member of aldehyde family with a simplest organic molecule, used in various industries. The aim of this experimental study was to investigate the effects of simultaneous formaldehyde and noise exposure on hormonal pituitary-gonadal axis in adult male mice.

Methods: 46 adult male mice were randomly assigned to one control group and three experimental groups which were exposed to formaldehyde vapor (10 ppm) (F), noise (100 dB) (N), and simultaneous formaldehyde with noise (NF), respectively for 10 days (8 hours a day). At the end of the experiment half of the mice of each group were sacrificed 24 hours after exposure (short-term effects) and the rest were sacrificed 35 days after the end of exposure (long-term effects). Plasma concentrations of testosterone, LH, FSH were measured using the ELISA method.

Results: In short-term analysis, the serum testosterone in groups N, F, and NF were 2.73±0.24, 2.58±0.16, and 2.03±0.22,(Ng/ml)respectively which had a significant decrease (p<0.001)compared to control group(3.82±0.35). The LH level in groups F, and NF also showed significant reduction compared to control group (p<0.05 and p<0.001).

Conclusion: Reduction of serum testosterone and LH level may be potentiated by noise (700-5700 HZ) in the simultaneous exposure to formaldehyde and noise.

Keywords

formaldehyde noise sexual hormones mice

© 2013, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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