The effect of endurance training on amount of nicotinic zcetylcholine receptors (nAChR) in fast and slow twitch muscle of male Wistar rats

AUTHORS

Zeynab Gorgin Karaji 1 , * , Abdolhosseyn Parnoo 2 , Reza Gharakhanlou 3 , Somaye Rajabi 4

1 SAMA Technical and Vocational Training College, Islamic Azad University, Kermanshah Branch, Kermanshah, Iran

2 Dept. of Sport Physiology, Faculty of Physical Education & Sport Sciences, Razi University, Kermanshah, Iran

3 Dept. of Physical Education & Sport Sciences, Faculty of Humanity, Tarbiat Modares University, Tehran, Iran

4 Dept. of Sport Physiology, Faculty of Humanity, Islamic Azad University, Shahroud, Iran

How to Cite: Gorgin Karaji Z, Parnoo A, Gharakhanlou R, Rajabi S. The effect of endurance training on amount of nicotinic zcetylcholine receptors (nAChR) in fast and slow twitch muscle of male Wistar rats, J Kermanshah Univ Med Sci. 2013 ; 16(7):e77287.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 16 (7); e77287
Published Online: February 27, 2018
Article Type: Research Article
Received: March 06, 2012
Accepted: July 17, 2012

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Abstract

Background: The purpose of the present study was to investigate the effect of endurance training on amount of nicotinic acetylcholine receptors (nAChR) in fast and slow twitch muscles of male Wistar rats.

Methods: A number of 15 male Wistar rats randomly divided into two groups of Control (n=7) and Endurance training (n=8). The endurance training treadmill running (for 12 consecutive week, 5 days a week, 60 min/day, 30 m/min speed) was performed by animals in endurance group. Forty-eight hours after last session of protocol, animals were anaesthetized and Anterior Tibialis (AT) and Soleus (SOL) muscles were removed. After removal, separated tissues were immersed quickly in liquid nitrogen and kept at -70 °C for later using. The amount of nAChR was measured using ELISA method. For data analysis, independent- sample t test was used.

Results: The results showed that there was a significant difference in amount of nAChR between control and endurance training groups at fast twitch muscle followed by endurance training (p=0.01). There was also a significant difference in amount of nAChR between control and endurance training groups at slow twitch muscle (P<0.001). However, data analysis showed that there was no significant difference in amount of nAChR between training and control groups at fast and slow twitch muscles followed by endurance training (P<0.001).

Conclusion: Exercise training probably play an important role in increasing amount of nAChR in fast and  slow twitch muscles of male Wistar rats.

Keywords

nAChR endurance training fast twitch muscle slow twitch muscle rat

© 2013, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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