The effect of different oral dose Diazepam on preventing seizure in Febrile Convulsion

AUTHORS

Mitra Hemmati 1 , Mansour Rezaei 2 , *

AUTHORS INFORMATION

1 Dept. of Pediatrics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Dept. of Biostatistics, Social Development and Health Promotion Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 16 (2); e78820
Published Online: July 29, 2012
Article Type: Research Article
Received: July 05, 2011
Accepted: December 20, 2011

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Abstract

Background: Febrile convulsion (FC) is one of the most common causes of seizure in children. Oral Diazepam or oral Midazolam are two mostly recommended drugs for FC prevention, but the effectiveness of these drugs remains controversial. Prophylactic use of oral anticonvulsant drugs is thus a questionable practice. This study was carried out to compare the effect of using different Diazepam dose on the prevention of seizure in FC.

Methods: In this study 186 child’s 6-60 month in Imam Reza Hospital of Kermanshah in 2007 following the first FC were divided into three groups based on the rate of diazepam consumption: group A (76s) received oral diazepam 1 mg/kg/day, group B (77s) received oral diazepam 0.4-0.6 mg/kg/day and group C (33s) fever didn’t received no oral diazepam. Then recurrence rate of seizure and demographic data of the subjects such as family background with regards to FC, after the treatment, were documented and analyzed the subjects were studied for 24 months.

Results: Recurrence rate of febrile seizure in groups A, B and C were 23.7%, 23.4% and 24.2%), respectively. Regarding rate recurrence of febrile seizure no statistically significant difference between 3 groups were found (P=0.930). Recurrence rate of seizure were much common among subjects with family background of febrile convulsion (P<0.05).

Conclusion: Results of this study showed that using different doses of oral diazepam at the beginning of and during FC couldn’t decrease the recurrent rate of seizure.

Keywords

Febrile Convulsion Diazepam recurrent rate

© 2012, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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