Advanced maternal age relationship with pregnancy complications


Farahnaz Keshavarzi 1 , * , Mansour Rezaei 2 , Shirin Iranfar 3 , Taravat Fakheri 1 , Anisodolleh Nankali 1 , Azam Imani 4


1 Dept. of Obstetrics and Gynecology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Dept. of Biostatistics and Epidemiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

3 Dept. of Medical Education, Kermanshah University of Medical Sciences, Kermanshah, Iran

4 Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran


Journal of Kermanshah University of Medical Sciences: 15 (3); e79358
Published Online: September 19, 2011
Article Type: Research Article
Received: May 13, 2010
Accepted: October 19, 2010




Background: Due to increase in pregnancy complications in advanced age, this study was conducted to assess the relationship between advanced maternal age and the pregnancy complications.

Methods: Pregnant women who admitted to the Motazedi hospital in Kermanshah were included in this analytic–cross sectional study. The study group was 1178 cases that divided into two sub-groups; 35-40 year-old (914) and over 40 years old (264); and 2038 subjects of 20-25 year-old recruited as control group. Data such as maternal age, maternal and neonatal complications were extracted from hospital recorded profiles and analyzed using Chi-square, Fisher and ANOVA statistical tests.

Results: The results showed that in case groups (35-40 and over 40 year-old): eclampsia (3.7%, 2.27%), gestational diabetes (1.8%, 4.2%), placenta previa (1.1%, 1.5%), placenta abruption (1.8%, 4.2%) were higher than the control group (0.28%, 0.5%, 0.2% and 1%) respectively.

Fetal and neonatal outcomes such as intrauterine fetal death (9.6%, 14%), macrosomia (4%, 1.9%), Apgar score<7 in 5th minutes (3.1%,2.3%) and meconium passage (9.5%,2.3%), in study groups (35-40 and over 40 year-old) have been increased compare to  the control group (5.2%,0.1%,0.8% and 0.9%) respectively.

Conclusion: We concluded that with increasing maternal age, eclampsia, gestational diabetes, placenta previa, placental abruption, intrauterine fetal death, and meconium passage increased, however, preterm labor and prolonged pregnancy have been reduced.


advanced maternal age maternal outcomes neonatal outcomes

© 2011, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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