Autoimmune thyroid disorder in patient with chronic hepatitis C before treatment

AUTHORS

Mehr Ali Rahimi 1 , Babak Sayad 2 , Ahmad Tahamoli Roudsari 3 , * , Karoun Shahebrahimi 1 , Maria Shirvani 4 , Mansour Rezaei 5

AUTHORS INFORMATION

1 Dept of Internal Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Dept. of Infectious Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

3 Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

4 Hepatitis Research Center, Emam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

5 Dept. of Biostatistics and Epidemiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

How to Cite: Rahimi M A, Sayad B, Tahamoli Roudsari A, Shahebrahimi K, Shirvani M, et al. Autoimmune thyroid disorder in patient with chronic hepatitis C before treatment, J Kermanshah Univ Med Sci. 2011 ; 15(3):e79361.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 15 (3); e79361
Published Online: September 19, 2011
Article Type: Research Article
Received: May 15, 2010
Accepted: October 05, 2010

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Abstract

Background: Creating autoantibodies against thyroid in hepatitis C patients who are being treated with interferon is now recognized for several years. Recently, some studies have claimed that prevalence of autoimmune thyroid disorders in Hepatitis C patients is higher when they are not treated by interferon and/or at the beginning of diagnosis, however the area still remained controversial. In order to analyze autoimmune thyroid disorders in Hepatitis C patients who are not still treated by interferon and compare them with the control group this study has been conducted.

Methods: A Case-Control study including 86 chronic hepatitis C patients before commencing treatment by interferon and 86 healthy volunteer individuals were examined. Data was collected using demographic and clinical variables questionnaires from both groups. FT4, TSH, Anti TPO and Anti TG examinations carried out in both group.

Results: The findings of this study showed increase Anti TPO in 4 cases in 13 case, increased is Anti TG in 5 case, sub clinical hypothyroid, ism sub clinical hyperthyroid in 3 ism and hyperthyroid ism in one case in the case group were observed.  There was no significant difference between the case and the control group.

Conclusion: We can conclude that there is no relationship between chronic hepatitis C infection and autoimmune thyroid.

Keywords

hepatitis C thyroid autoimmunity Anti TPO Anti TG

© 2011, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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