Determination of Rifampin and Isoniazid resistant mycobacterium tuberculosis in Kermanshah (2006-2008)

AUTHORS

Babak Izadi 1 , Malek Kanani 1 , * , Sedigheh Khazaei 1 , Sayed Hamid Madani 1

AUTHORS INFORMATION

1 Dept. of Pathology. Molecular Pathology Research Center, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

How to Cite: Izadi B, Kanani M, Khazaei S, Madani S H. Determination of Rifampin and Isoniazid resistant mycobacterium tuberculosis in Kermanshah (2006-2008), J Kermanshah Univ Med Sci. 2011 ; 15(2):e79383.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 15 (2); e79383
Published Online: July 19, 2011
Article Type: Brief Report
Received: May 31, 2010
Accepted: August 03, 2010

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Abstract

Tuberculosis is one of the most important infectious diseases and a major cause of morbidity and mortality in developing countries. Multi drug resistant tuberculosis is a new threat, which can result in a high case fatality rate. This study was conducted to define the incidence of multidrug resistant tuberculosis in Kermanshah. ­Antibiogram was performed on­­ PCR-confirmed isolates of mycobacterium tuberculosis by using the proportion method. Eight cases (57.1%) showed resistance to ­1µg/ml Isoniazid­. Resistance to Rifampicin was identified in 46.2% ­of cases.­ This study showed a high rate of single drug and multidrug resistance. We recommend antibiogram for all cases of tuberculosis.

Keywords

tuberculosis multidrug resistance

© 2011, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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