Angiogenesis and tumor

AUTHORS

Kamran Mansouri 1 , * , Ali Mostafaie 1 , Hamid-Reza Mohammadi-Motlagh 1

1 Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

How to Cite: Mansouri K , Mostafaie A, Mohammadi-Motlagh H. Angiogenesis and tumor, J Kermanshah Univ Med Sci. 2011 ; 14(4):e79444.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 14 (4); e79444
Published Online: March 19, 2011
Article Type: Review Article
Received: November 24, 2009
Accepted: May 25, 2010

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Abstract

Angiogenesis, the process of new blood vessel formation from existing ones, plays an important role in  the physiologic circumstances such as embryonic development, placenta formation, and wound healing. It is also crucial to progress of pathogenic processes of a variety of disorders, including tumor growth and metastasis. In general, angiogenesis process is a multi-factorial and highly structured sequence of cellular events comprising migration, proliferation and differentiation of endothelial cells and finally vascular formation, maturation and remodeling.Thereby, angiogenesis inhibition as a helping agent to conventional therapies such as chemotherapy and radiation has attracted the scientists’ attentions studying in this field.

Keywords

angiogenesis tumor metastasis

© 2011, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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