Comparing ultra rapid opiate detoxification with Methadone in recurrent of self-introduced addicted subjects

AUTHORS

Hosein Farzam 1 , Khosro Farhadi 1 , Mansour Rezaei 2 , * , Alireza Tolouee 3

1 Dept. of Anestesiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Social Development Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

3 School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

How to Cite: Farzam H, Farhadi K, Rezaei M, Tolouee A. Comparing ultra rapid opiate detoxification with Methadone in recurrent of self-introduced addicted subjects, J Kermanshah Univ Med Sci. 2010 ; 14(3):e79470.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 14 (3); e79470
Published Online: December 19, 2010
Article Type: Research Article
Received: November 11, 2009
Accepted: April 20, 2010

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Abstract

Background: The common detoxification method is replacement of long effect opiate by short effect opiate and then reducing its amount gradually. More modern method is ultra rapid opiate detoxification (UROD) by opiate antagonists, which is performed by general anesthesia. The advantages of two methods have not been confirmed. This study aimed to compare effectiveness and withdrawal rate in both methods following up to a year.

Methods: 211 self-introduced patients who referred to Farabi hospital for withdrawal were enrolled in this cross sectional study during 2005-06. The patients underwent detoxification after psychiatry screening and addiction confirmation. They divided into two detoxified method groups (110 patients in UROD and 101 Methadone). Recurrent and suspected cases were confirmed or rejected by urinary test and more specific test respectively. Data was collected from available patients profiles and contacting with patients or their relatives and was analyzed using Chi-square & independent sample T-test.

Results: The results showed that addiction recurrent in UROD and Methadone groups was 35.7% and 56.4% respectively (P=0.002). The average age of recurrent subjects in UROD group was younger than successful population at that same group (27.95±5.2 vs. 31.4±7.1 years old, p=0.008).

Conclusion: This study suggested that chance of detoxification and successful withdrawal by UROD method is higher than Methadone method and younger patients are more likely to get the recurrence. It is recommended to compare these two methods in a prospective study by unifying both groups based on age and considering opiate use duration.

Keywords

UROD methadone replacement recurrence self-introduced

© 2010, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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