Serum Antioxidant Markers in Patients with Major and Minor B-thalassemia

AUTHORS

Jafar Nowrouz-Zadeh 1 , * , E Eftekhar 1 , M Chiani 1 , S Hejazi 1

1 Iran

How to Cite: Nowrouz-Zadeh J, Eftekhar E, Chiani M, Hejazi S. Serum Antioxidant Markers in Patients with Major and Minor B-thalassemia, J Kermanshah Univ Med Sci. 2008 ; 12(1):e80108.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 12 (1); e80108
Published Online: June 19, 2008
Article Type: Research Article
Received: August 19, 2007
Accepted: April 22, 2008

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Abstract

Materials & Methods: Patients with major b-thalassemia or individuals with minor thalassemia (Age range: 2-12 years and 29-46 years, respectively; n=20 each) and 20 age and sex matched control subjects were recruited. Serum glutathione (GSH) , superoxide dismutase and catalase (CAT) were determined spectrophotometrically. Data were analysed by t-test.

Results: Glutathione levels were markedly lower in patients with b-thalassemia major than in the controls (P<0.05) whilst no differences were seen in either in the activities of catalase or superoxide dismutase. On the contrary, no differences were observed in individuals with minor thalassemia .When patients with major b-thalassemia and individuals with minor thalassemia were compared a marked reduction in GSH levels and increased in CAT activity were noted in the patient group (P<0.05).   

Conclusion:  The data implies disturbance in antioxidant system in patients with major b-thalassemia as measured by a marked reduction of serum glutathione as the first line of defence against free radical attacks and increased in the activity of CAT. This condition eventually leads to cellular tissue damage. Antioxidant therapy may, therefore, prove useful in protecting against tissue damage.

Keywords

Major Beta-thalassemia Minor Beta-thalassemia Antioxidant Iron overload

© 2008, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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