A 5-Year- study on Children with Acute Myelocytic Leukemia/AML, Ahvaz Shafa Hospital (1996-2001)

AUTHORS

Reza Akramipour 1 , * , M Pedram 1 , KM Zandian 1 , A Hashemi 1

AUTHORS INFORMATION

1 Iran

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 11 (2); e80674
Published Online: September 19, 2007
Article Type: Research Article
Received: November 27, 2004
Accepted: May 01, 2007

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Abstract

Introduction: AML is the second most common leukemia in children after ALL. The rate of AML in 14-year-old children is reported to be 6.6 cases per million. This study reviews 40 children with AML within 5 years. These patients have been evaluated for clinical findings and overall survival.

Materials & Methods: All Patients with AML have been evaluated from 1996 to 2000 for clinical findings, age, gender, lab data, AML subtypes, geographic distribution, treatment results and overall survival. Myeloblast, over 30 percent, was compatible with AML. FAB classification was applied for AML subtypes. BM flocytometry and special staining were applied, if necessary. CBC test was performed through sysmex counter.

Results: In this study, 40 cases were diagnosed to have AML during 5 years, 60% of patients were male & 40% female, among whom 17.5% were less than one year old. Age distribution was between 2 to 15 years old, and the most common clinical findings were bleeding, weakness, respiratory symptoms and pallor. More than 90 percent of patients suffered from anemia and thrombocytopenia.  M3 was the most common subtype.

Conclusion: In this survey, overall survival was less than 35 percent, which proves that chemotherapy without BMT is an incomplete therapy; there was also no significant difference between sexes, but 17.5% of patients were less than one year old and 22.5% of them reported by parents to have anemia.

Keywords

leukemia AML Survival Rate

© 2007, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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