Effects of alkylbenzene sulfonate on rat's brain AMP deaminase activity

AUTHORS

D Ghoojagh 1 , * , AM Ghazi Mirsaeed 1 , M Ahanjan 1

AUTHORS INFORMATION

1 Iran

How to Cite: Ghoojagh D, Ghazi Mirsaeed A, Ahanjan M. Effects of alkylbenzene sulfonate on rat's brain AMP deaminase activity, J Kermanshah Univ Med Sci. 2002 ; 6(2):e81004.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 6 (2); e81004
Published Online: September 19, 2002
Article Type: Research Article
Received: April 11, 2002
Accepted: September 11, 2002

Crossmark

CHEKING

READ FULL TEXT
Abstract

Introduction and Objective: Alkylbenzene sulfonate is used as surfactant and, being discarded into rivers, it acts as an  environmental pollutant. The enzyme  AMP deaminase  may be potentially useful in delineating the possible mechanisms of biological toxicity of alkylbenzene sulfonate.

Materials and Methods:  We studied the effects of alkylbenzene sulfonate on rat's brain AMP deaminase activity  by measuring ( with spectrophotometry) the enzyme activity with and without exposure to  5-10 micromole  concentrations of alkylbenzene sulfonate, using 30 specimens in each study arm.

Results: Enzyme activity in presence and absence of exposure to alkylbenzene sulfonate was 92.85±8.52  and 18.31±2.45 nmol/min/gr brain protein, respectively.

Discussion and Conclusions: Alkylbenzene sulfonate may inhibit AMP deaminase  by reacting to its active site. Our results may be used to understand the toxicity of alkylbenzene sulfonate.

Keywords

Alkylbenzene sulfonate AMP deaminase environmental pollutant.

© 2002, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Fulltext

The full text of this article is available on PDF

COMMENTS

LEAVE A COMMENT HERE: