The Effect of the "Falcaria Vulgaris" on Deep Skin Wound Remodeling Time and Skin Tension Power in Rats
Journal of Kermanshah University of Medical Sciences: December 20, 2006, 10 (3); e81802
December 19, 2006
Article Type: Research Article
November 22, 2004
November 11, 2006
B. The Effect of the "Falcaria Vulgaris" on Deep Skin Wound Remodeling Time and Skin Tension Power in Rats,
J Kermanshah Univ Med Sci.
Introduction: "Ghaze-yaghi" (Falcaria Vulgaris) is a plant from "Umbelliferae" family which has been used traditionally for skin wound healing in Kermanshah as dried powder. Since there have been less studies on the effect of this plant, this study has been done to see the effect of flacaria vulgaris on deep skin wound remodeling time and skin tension power in rats.
Materials & Methods: This study was done on mature male rats in two parts. In first part dried powder of the plant was used as test and fiberglass powder as placebo and in second part alcoholic extract (5% and 10% in two separate groups) was used as test and ethanol 96º as placebo. After making the animals unconscious, two skin incision with 4cm length was made on the each side of vertebra column of rats. In the half of rats the right side and in the others the left side was selected as a test side and the other side as a control side. After making incision it was dressed with the plant and placebo for fifteen days. Wound surface was measured on third, sixth and sixteenth days. On sixteenth day a skin flap was provided and quantity of the skin tension power was measured and then flaps were sent to histological study. Results were analyzed with paired t-test.
Results: In the first part the mean difference between the wound surface in test and control on third, sixth and sixteenth days was significant (P.V=0.035, 0.008 and 0.002), but not for skin tension power. In the second part the mean difference between the wound surface in test and control sides in each rat for both two groups was significant (P.V=0.03, 0.001 and 0.03 for %5 extract and P.V=0.01, 0.001 and 0.03 for %10 extract).The mean difference between the skin tension power of the test and control sides in each rat was significant (pv: 0.02) by using 5% but not for 10%.There was no significant difference between test and controlled by histological study.
Conclusion: "Ghaze-yaghi" has positive effects on the skin wound healing. It is recommended that more studies be done for finding the mechanism which makes these effects influential.
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