Journal of Kermanshah University of Medical Sciences

Published by: Kowsar

The Effectiveness of Computer-Based Cognitive Rehabilitation in Executive Functions in Patients with Multiple Sclerosis

Avat Sharifi 1 , Kamran Yazdanbakhsh 1 , * and Khodamorad Momeni 1
Authors Information
1 Department of Psychology, Razi University, Kermanshah, Iran
Article information
  • Journal of Kermanshah University of Medical Sciences: 23 (1); e83092
  • Published Online: March 2, 2019
  • Article Type: Research Article
  • Received: August 8, 2018
  • Revised: October 7, 2018
  • Accepted: January 1, 2019
  • DOI: 10.5812/jkums.83092

To Cite: Sharifi A, Yazdanbakhsh K, Momeni K. The Effectiveness of Computer-Based Cognitive Rehabilitation in Executive Functions in Patients with Multiple Sclerosis, J Kermanshah Univ Med Sci. Online ahead of Print ; 23(1):e83092. doi: 10.5812/jkums.83092.

Copyright © 2019, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Lanzillo R, Chiodi A, Carotenuto A, Magri V, Napolitano A, Liuzzi R, et al. Quality of life and cognitive functions in early onset multiple sclerosis. Eur J Paediatr Neurol. 2016;20(1):158-63. doi: 10.1016/j.ejpn.2015.08.005. [PubMed: 26387071].
  • 2. Drew M, Tippett LJ, Starkey NJ, Isler RB. Executive dysfunction and cognitive impairment in a large community-based sample with multiple sclerosis from New Zealand: A descriptive study. Arch Clin Neuropsychol. 2008;23(1):1-19. doi: 10.1016/j.acn.2007.09.005. [PubMed: 17981008].
  • 3. Mattioli F, Stampatori C, Zanotti D, Parrinello G, Capra R. Efficacy and specificity of intensive cognitive rehabilitation of attention and executive functions in multiple sclerosis. J Neurol Sci. 2010;288(1-2):101-5. doi: 10.1016/j.jns.2009.09.024. [PubMed: 19825502].
  • 4. Bayrami M, Hassimi T, Taher Akdam A, Alilou M, Nikzad B. [Comparison of cognitive performances in patients with multiple sclerosis with healthy people]. Iran J Rehab Res. 2015;1(3):13-23. Persian.
  • 5. Aliloo M, Hashemi Nasab T, Mahamood Fallahi A. [Comparing executive functions inhibition response and sustained attention in children with learning disabilities in mathematics and normal children]. J Thought Behav Clin Psychol. 2014;9(35):27-36. Persian.
  • 6. Rao SM, Leo GJ, Bernardin L, Unverzagt F. Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology. 1991;41(5):685-91. [PubMed: 2027484].
  • 7. Mikola JM. Communicative competence in persons with aphasia: The impact of executive function. Michigan: Wayne State University; 2010.
  • 8. Frouzi S, Ebrahimighavam S, Dortaj F. [Copmparison of executive functions based on test anxiety in the fifth grade elementary students]. Knowledge Res Appl Psychol. 2011;12(1):76-85. Persian.
  • 9. Bashi Abdolabadi H, Pilevar S, Saram AA. [The effect of cognitive rehabilitation on cognitive function, memory, depression, and anxiety in patients with multiple sclerosis]. Neurosci J Shefaye Khatam. 2016;4(3):28-40. Persian. doi: 10.18869/acadpub.shefa.4.3.28.
  • 10. Wolters G, Stapert S, Brands I, Van Heugten C. Coping styles in relation to cognitive rehabilitation and quality of life after brain injury. Neuropsychol Rehabil. 2010;20(4):587-600. doi: 10.1080/09602011003683836. [PubMed: 20446171].
  • 11. Bergo E, Lombardi G, Pambuku A, Della Puppa A, Bellu L, D'Avella D, et al. Cognitive rehabilitation in patients with gliomas and other brain tumors: State of the art. Biomed Res Int. 2016;2016:3041824. doi: 10.1155/2016/3041824. [PubMed: 27493954]. [PubMed Central: PMC4963561].
  • 12. Willis SL, Tennstedt SL, Marsiske M, Ball K, Elias J, Koepke KM, et al. Long-term effects of cognitive training on everyday functional outcomes in older adults. JAMA. 2006;296(23):2805-14. doi: 10.1001/jama.296.23.2805. [PubMed: 17179457]. [PubMed Central: PMC2910591].
  • 13. Gaitan A, Garolera M, Cerulla N, Chico G, Rodriguez-Querol M, Canela-Soler J. Efficacy of an adjunctive computer-based cognitive training program in amnestic mild cognitive impairment and Alzheimer's disease: A single-blind, randomized clinical trial. Int J Geriatr Psychiatry. 2013;28(1):91-9. doi: 10.1002/gps.3794. [PubMed: 22473855].
  • 14. Rahmani M, Rahimian Boogar I, Talepasand S, Nokani M. [The effectiveness of computer-based cognitive rehabilitation on improvement of working memory and executive functions among women with multiple sclerosis]. Psychol Stud. 2017;13(3):59-76. Persian.
  • 15. Amato MP, Goretti B, Viterbo RG, Portaccio E, Niccolai C, Hakiki B, et al. Computer-assisted rehabilitation of attention in patients with multiple sclerosis: Results of a randomized, double-blind trial. Mult Scler. 2014;20(1):91-8. doi: 10.1177/1352458513501571. [PubMed: 23959713].
  • 16. Shahgholian M, Azadfllah P, Fathi Ashtiani A, khodadadi M. [Design of the Wisconsin card test software: Theoretical foundations, how to build and psychometric properties]. Clin Psychol Stud. 2011;1(4):111-133. Persian.
  • 17. Chiaravalloti ND, Genova HM, DeLuca J. Cognitive rehabilitation in multiple sclerosis: The role of plasticity. Front Neurol. 2015;6:67. doi: 10.3389/fneur.2015.00067. [PubMed: 25883585]. [PubMed Central: PMC4383043].
  • 18. Hanssen KT, Beiske AG, Landro NI, Hofoss D, Hessen E. Cognitive rehabilitation in multiple sclerosis: A randomized controlled trial. Acta Neurol Scand. 2016;133(1):30-40. doi: 10.1111/ane.12420. [PubMed: 25952561].
  • 19. Plohmann AM, Kappos L, Ammann W, Thordai A, Wittwer A, Huber S, et al. Computer assisted retraining of attentional impairments in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry. 1998;64(4):455-62. [PubMed: 9576535]. [PubMed Central: PMC2170026].
  • 20. Khalili L, Dolatshahi B, Farhodi M, Pourshahbaz A, Niknam Z. [The efficacy of attention rehabilitation in decreasing focused attention and continuous attention deficits on multiple sclerosis patients]. Modern Psychol Res. 2012;7(23):39-64. Persian.
  • 21. Fink F, Rischkau E, Butt M, Klein J, Eling P, Hildebrandt H. Efficacy of an executive function intervention programme in MS: A placebo-controlled and pseudo-randomized trial. Mult Scler. 2010;16(9):1148-51. doi: 10.1177/1352458510375440. [PubMed: 20621945].
  • 22. Kesler SR, Lacayo NJ, Jo B. A pilot study of an online cognitive rehabilitation program for executive function skills in children with cancer-related brain injury. Brain Inj. 2011;25(1):101-12. doi: 10.3109/02699052.2010.536194. [PubMed: 21142826]. [PubMed Central: PMC3050575].
  • 23. Faria AL, Andrade A, Soares L, I. Badia SB . Benefits of virtual reality based cognitive rehabilitation through simulated activities of daily living: A randomized controlled trial with stroke patients. J Neuroeng Rehabil. 2016;13(1):96. doi: 10.1186/s12984-016-0204-z. [PubMed: 27806718]. [PubMed Central: PMC5094135].
  • 24. Ghamarigivi H, Maghsoud N, Dehghani F. [Investigation of cognitive rehabilitation on restruction of executive functions of obsessive-compulsive patients]. Clin psychol Stud. 2014;4(16):101-28. Persian.
  • 25. Abdi A, Dana A, Hatami J, Parand A. [The effect of cognitive computer games on working memory, attention and cognitive flexibilityn in students with attention deficit/hyperactivity disorder]. J Except Child. 2014;14(1):19-34. Persian.
  • 26. Mahmoudi khurandy Z, Talepasand S, Rahimian Bogar I. [The impact of computer-based cognitive rehabilitation program on Alzheimer's patients with mild cognitive deficits]. Adv Cogn Sci. 2016;17(4):22-32. Persian.
  • 27. Fazeli M, Ehteshamzadeh P, Hashemi Sheikh Bahani E. [The effectiveness of cognitive behavior therapy on cognitive flexibility of depressed people]. J Thought Behav Clin Psychol. 2014;9(34):27-36. Persian.
  • 28. Khalili L, Dolatshahi B, Farhodi M, Niknam Z, Poursh Ahbaz A. [The effectivness of attention rehabilitation in decreasing focused attention and working memory deficits on multiple sclerosis patients]. J Urmia Univ Med Sci. 2014;25(5):382-396. Persian.
  • 29. Nokani M. [Computer-assisted cognitive remediation (rehabilitation) in attention deficits of ADHD (inattentive type)]. Tehran: University of Social Welfare and Rehabilitation Science; 2010. Persian.
  • 30. Draganski B, Gaser C, Busch V, Schuierer G, Bogdahn U, May A. Neuroplasticity: Changes in grey matter induced by training. Nature. 2004;427(6972):311-2. doi: 10.1038/427311a. [PubMed: 14737157].
  • 31. Penner IK, Opwis K, Kappos L. Relation between functional brain imaging, cognitive impairment and cognitive rehabilitation in patients with multiple sclerosis. J Neurol. 2007;254 Suppl 2:II53-7. doi: 10.1007/s00415-007-2013-6. [PubMed: 17503130].
  • 32. Hardy KK, Willard VW, Allen TM, Bonner MJ. Working memory training in survivors of pediatric cancer: A randomized pilot study. Psychooncology. 2013;22(8):1856-65. doi: 10.1002/pon.3222. [PubMed: 23203754]. [PubMed Central: PMC4131851].
  • 33. O'Connel RG, Bellgrove MA, Robertson IH. Avenues for the neuro-remediation of ADHD: Lessons from clinical neurosciences. In: Fitzgerald M, Bellgrove M, Gill M, editors. Handbook of attention deficity hyperactivity disorder. West Sussex: Wiley Blackwell; 2007. p. 441-63.

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