Effects of adding dexmedetomidine to lidocaine on the onset and duration of axillary block for upper extremity surgeries

AUTHORS

Behrooz Zaman 1 , Samad Noorizad 1 , Seyed Alireza Seyed Siamdoust 1 , Seyed Hassan Etemadi 1 , Sina Askarian Omran 2 , Mahzad Alimian 1 , *

1 Dept. of Anesthesiology and Regional Anesthesia, Iran University of Medical Sciences, Tehran, Iran

2 Anesthesiologist, Aja Hospital, Hormozgan, Iran

How to Cite: Zaman B, Noorizad S , Seyed Siamdoust S A, Etemadi S H, Askarian Omran S, et al. Effects of adding dexmedetomidine to lidocaine on the onset and duration of axillary block for upper extremity surgeries, J Kermanshah Univ Med Sci. 2017 ; 21(3):e69237.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 21 (3); e69237
Published Online: December 30, 2017
Article Type: Original Article
Received: August 12, 2017
Accepted: November 07, 2017

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Abstract

Introduction: Dexmedetomidine, which is an alpha 2 agonist, reduces the transmission of pain signals and has an independent inhibitory effect on nerve action potential. The purpose of this study was to examine the effects of adding dexmedetomidine to lidocaine in an axillary block.

Methods: In this randomized, double-blind study 40 patients included patients were divided randomly into two groups of 20: In the first group, 39 cc of 1% lidocaine plus 1cc of normal saline was administered and the 2nd group received dexmedetomidine 1cc (100µg) in addition to 39 cc of 1% lidocaine. The onset and persistence of the sensorimotor block and hemodynamic changes including heart rate and systolic and diastolic blood pressure before, during, and after surgery were compared.

Results: Age, sex, type of surgery, duration of surgery, and other demographic characteristics were not significantly different in two groups (P>0.05). Onset of the sensory and motor block was similar in both groups, but the persistence of the sensory and motor block and analgesia in the treatment group was significantly higher (P<0.05). The VAS score was lower in cases than controls. Hemodynamic change differences between the two groups were statistically significant (P<0.05).

Conclusion: The results of this study showed that adding dexmedetomidine to lidocaine in an axillary block did not alter the onset of the sensory and motor block, but the sensory and motor block duration and analgesia was increased. Despite significant differences in hemodynamic responses between the two groups, these changes were not clinically significant in ASA1 patients.

Keywords

Lidocaine dexmedetomidine axillary block sensory block motor block hemodynamic sensory-block motor-block

© 2017, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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