Dexmedetomidine versus Propofol in reducing postoperative nausea and vomiting in gynecologic laparoscopic surgery

AUTHORS

Mansour Choubsaz 1 , Mansour Rezaei 2 , Aida Lahoorpour 1 , * , Rasoul Mahdavi Jafari 1

1 Department of Anesthesiology, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Department of Biostatistics, Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

How to Cite: Choubsaz M , Rezaei M , Lahoorpour A , Jafari R M . Dexmedetomidine versus Propofol in reducing postoperative nausea and vomiting in gynecologic laparoscopic surgery, J Kermanshah Univ Med Sci. 2017 ; 21(2):e69283. doi: 10.22110/jkums.v21i2.3425.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 21 (2); e69283
Published Online: August 30, 2017
Article Type: Original Article
Received: May 16, 2017
Accepted: September 05, 2017
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Abstract

Introduction: Post-Operative Nausea and Vomiting (PONV) occurs in 20%-30% of patients, and is the second most common complaints after pain. This unpleasant complication can lead to rare but serious medical complications such as aspiration of gastric contents, suture dehiscence, esophageal rupture, subcutaneous emphysema, or pneumothorax. Annual PONV-related health care costs reach several hundred million dollars. Many interventions have been done to control PONV, but complications of drug interactions limit the use of drugs. For example, Dropridol has been placed on the Black Box Warning because of the risk of cardiac arrhythmias.

Methods: This clinical trial recruited 80 patients with American Society of Anesthesiologist (ASA) class I or II who were scheduled for elective gynecologic laparoscopic surgery. They were randomly divided into two groups: Propofol and Dexmedetomidine. The data was collected by the first nurse in PACUs and the second nurse in post-surgery ward, including age, weight, smoking history, nausea, vomiting and severity of vomiting. Patients and observers were blinded to the prescribed hypnotic drugs. The severity of nausea was assessed by visual analogue scale (ranging 0 to 10) in 0-2, 2-6 and 6-24 hours. The state of nausea was also recorded.

Results: The incidence of nausea and the severity of vomiting significantly decreased in the dexmedetomidine group compared to the Propofol group (PV=0.001).

Conclusion: The results showed that Dexmedetomidine can reduce the incidence of nausea and severity of vomiting compared to Propofol.

Keywords

Propofol Dexmedetomidine postoperative nausea and vomiting visual analog scale

© 2017, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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