Lack of association between Interleukin-12 gene polymorphism (rs568408 G/A) and susceptibility to chronic hepatitis B virus infection

AUTHORS

Seddigheh Heidarian 1 , Farzaneh Sabahi 1 , * , Seyed Reza Mohebbi 2 , ** , Mohammad Reza Zali 3

1 Department of Virology, Tarbiat Modares University, Tehran, Iran

2 Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Corresponding Authors:

How to Cite: Heidarian S, Sabahi F, Mohebbi S R, Zali M R. Lack of association between Interleukin-12 gene polymorphism (rs568408 G/A) and susceptibility to chronic hepatitis B virus infection, J Kermanshah Univ Med Sci. 2016 ; 20(1):e69747. doi: 10.22110/jkums.v20i1.2685.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 20 (1); e69747
Published Online: June 19, 2016
Article Type: Original Article
Received: October 27, 2015
Accepted: April 05, 2016
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Abstract

Introduction: Hepatitis B is a potentially life-threatening infection that causes acute infection and chronic hepatitis with progression to cirrhosis and hepatocellular carcinoma (HCC). Interleukin-12 (IL12) is responsible for activation of Th1 immune responses, leading to possible clearance of HBV infection from the host’s body. The host’s immune-genetic background plays an important role in the pathogenesis of infectious diseases. The aim of the present study was to investigate the association of interleukin 12A single nucleotide polymorphism (rs568408 G/A) with chronic HBV infection.

Methods: In this case-control study, 120 chronic HBV patients and 120 healthy controls were studied from 2013 to 2015. Genotype analysis was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.

Results: The genotype distribution of IL12 rs568408 G/A was not significantly different between the chronic HBV patients and healthy controls. The frequency rates of the IL12 gene polymorphism at position rs568408 included GG (64.2%), AG (33.3%), and AA (2.5%) in the HBV patients and GG (68.3%), AG (29.2%), and AA (2.5%) in healthy controls (p=0.728).

Conclusion: The results suggested no significant association between IL12A rs568408 G/A genotypes and chronic hepatitis B virus infection.

Keywords

Chronic hepatitis B infection single nucleotide polymorphisms Interleukin 12 Iran

© 2016, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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