The relationship between oral lichen planus and gastrointestinal symptoms


Mandana Khatibi 1 , Sareh Khalifeh 2 , * , Hasan Seirafi 3 , Masoud Dooghaee Moghadam 4 , Atena Akhavan Modares 5

1 Dept. of Oral and Maxillofacial Diseases, Islamic Azad university, Dental branch, Tehran, Iran. Member of Craniomaxillofacial research center, Tehran Dental branch,, Islamic Azad university, Tehran, Iran

2 Dept. of Oral and Maxillofacial disease, Islamic Azad University, Dental branch ,Tehran, Iran

3 Dept. of Skin disease, Tehran University of Medical Sciences, Tehran, Iran

4 Dept. of Gastrointestinal Diseases, Tehran University of Medical Sciences, Tehran, Iran

5 Dept. of General Dentistry, Tehran Islamic Azad University, Tehran, Iran

How to Cite: Khatibi M, Khalifeh S, Seirafi H, Dooghaee Moghadam M, Akhavan Modares A. The relationship between oral lichen planus and gastrointestinal symptoms, J Kermanshah Univ Med Sci. 2016 ; 19(7):e69756. doi: 10.22110/jkums.v19i7.2493.


Journal of Kermanshah University of Medical Sciences: 19 (7); e69756
Published Online: March 19, 2016
Article Type: Original Article
Received: August 22, 2015
Accepted: January 26, 2016




Background: Gastrointestinal complications, followed by involvement of gastrointestinal tract with oral lichen planus, are one of the problems of the patients with oral lichen planus. Gastrointestinal symptoms should be evaluated to reject malignancy probability (1-5%). Given lack of information and different reported frequencies in Iran and other countries, this study was conducted in order to evaluate the relationship between oral lichen planus and gastrointestinal symptoms in Razi hospital in Tehran.

Methods: This case-control study was performed on 50 patients with oral lichen planus and 50 controls by observation, clinical examination and biopsy, if necessary. Both groups were similar in sex, age, smoking, alcohol abuse and lack of systemic diseases. Gastrointestinal (GI) symptoms such as dysphagia, odynophagia, hunger pain, heartburn, flatus, etc. Were evaluated. Data were analyzed by SPSS statistical software using chi–square, Exact Fisher and T-student tests.

Results: Of 50 cases (OLP), 32(64%) patients and among 50 controls, 16 (32%) patients were found to have GI symptoms. Hunger pain (18%) and heartburn (18%) were the most common symptoms. Also, there was a significant difference in the prevalence of gastrointestinal symptoms between the two groups (P<0.005),

Conclusion: Gastrointestinal complications can be a part of mifestations of lichen planus and OLP. Knowledge of gastrointestinal symptoms in OLP patients can be helpful in preventing the G.I tract obstruction and malignancy by on time treatment.


Oral lichen planus (OLP) Gastrointestinal (GI )symptoms esophageal obstruction

© 2016, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.



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