Association between CTLA-4 polymorphism and systemic lupus erythematosus

AUTHORS

Mahdieh Shojaa 1 , Patricia Khashayar 2 , Mahsa Amoli 3 , Mehrdad Aghaie 4 , * , Mostafa Qorbani 5 , Mahmoud Akbarian 6 , Neda Ranjbar Pour 7 , Arghavan Kouroshnia 3

1 Deputy of Research and Technology, Golestan University of Medical Sciences, Gorgan, Iran

2 Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

3 Endocrinology & Metabolism Research Center (EMRC), Tehran University of Medical Sciences, Tehran, Iran

4 Dept. of Rheumatology, Faculty of Medicine, Bone Joint and Connective Tissue Research Center (BJCRC), Golestan University of Medical Sciences, Gorgan, Iran

5 Dept. of Public Health, Alborz University of Medical Sciencesand Non-communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

6 Rheumatology Research Center, Tehran University of Medical Sciences,Tehran, Iran

7 Genetic Department, Islamic Azad University, Tehran branch, Tehran, Iran

How to Cite: Shojaa M, Khashayar P, Amoli M, Aghaie M, Qorbani M, et al. Association between CTLA-4 polymorphism and systemic lupus erythematosus, J Kermanshah Univ Med Sci. 2014 ; 17(10):e74330. doi: 10.22110/jkums.v17i10.1167.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 17 (10); e74330
Published Online: January 29, 2014
Article Type: Research Article
Received: June 30, 2013
Accepted: October 29, 2013
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Abstract

Background: Cytotoxic lymphocyte antigen-4 (CTLA-4) plays an important role in regulating T cell activities. CTLA-4 gene polymorphisms are associated with genetic susceptibility to various autoimmune diseases, including systemic lupus erythematosus (SLE). The present study was conducted to analyze the role of CTLA-4 polymorphism at positions −1722TC in patients suffering from SLE.

Methods: Samples were collected from 180 SLE patients and 304 healthy people. Both groups were equal in terms of age and ethnicity. Polymerase chain reaction restriction fragments length polymorphism (PCR-RFLP) was used to analyze the genotype and allele frequencies of these polymorphisms. Data were analyzed by SPSS software.

Results: No statistically significant difference was observed between the studied genotypic and allelic frequencies, SLE patients and the controls. There was a significant correlation between age range 15-45 and TT genotype (P<0.0001). However,  no significant correlation was found between other risk factors and different genotypes.

Conclusion: The results suggested that 1722TC polymorphism in the promoter region of the CTLA-4 gene does not play any role in the genetic susceptibility to SLE.

Keywords

CTLA-4 1722TC systemic lupus erythematosus polymorphism promoter

© 2014, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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