Effects of endurance exercises on microarchitecture of proximal tibia in ovariectomized rats

AUTHORS

Valiollah Dabidiroshan 1 , * , Masomeh Nobahar 2

1 Dept. of Sport Physiology, School of Athletic Sciences, University of Mazandaran, Babolsar, Iran

2 Dept. of Athletic Sciences, Payam Noor University, Iran

How to Cite: Dabidiroshan V, Nobahar M. Effects of endurance exercises on microarchitecture of proximal tibia in ovariectomized rats, J Kermanshah Univ Med Sci. 2012 ; 15(6):e78897.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 15 (6); e78897
Published Online: March 19, 2012
Article Type: Research Article
Received: April 06, 2011
Accepted: September 13, 2011

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Abstract

Background: Appropriate endurance exercise can change bone mass density and strength of weight-bearing bones in both animals and humans, but its effects on the microstructure are not known. This study aimed to determine skeletal changes induced by the treadmill running endurance in ovariectomized adult mice.

Methods: twenty-seven adult female rats were divided into experimental and control groups.(Each group consisted of 9 rats)  and 9 rats were killed to determine baseline values. Experimental group performed the progressive running exercise for 8 weeks, 12 to 20 m/min, 10 to 59 min, 5 times per week. Microarchitecture of dense and spongy bone tissues in the proximal tibia epiphysis were measured by using a semi-automated image analysis system. Data was analyzed using t-student tests (P<0.05).

Results: Running on treadmill causes a significant increase in the thickness and volume of spongy tissue and bone tissue was dense and spongy epiphysis upper tibia (P<0.05). Compared to control, treadmill running group showed significant difference in trabecular thickness and separation. 

Conclusion: Ovariectomy may decrease the microarchitecture properties of cortical tissue and especially, trabecular tissue in weight-bearing bones. Increasing bone strength induced by endurance exercise is mediated by changes in bon microarchitecture. 

Keywords

weight-bearing exercise microarchitecture ovariectomized

© 2012, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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