Seroconversion rates after hepatitis-B vaccination in children

AUTHORS

Mandana Afsharian 1 , Mohammad Ghaderi 2 , Siavash Vaziri 1 , Zahra Leghaei 3 , Keighobad Ghadiri 2 , * , Alireza Janbaksh 1 , Babak Sayad 1 , Feizollah Mansouri 1 , Kourosh Nikzad 4

1 Dept. Of Infectious Disease, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Dept. of Pediatrics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

3 Dept. of Health of Kermanshah Province, Kermanshah University of Medical Sciences, Kermanshah, Iran

4 Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

How to Cite: Afsharian M, Ghaderi M, Vaziri S, Leghaei Z , Ghadiri K, et al. Seroconversion rates after hepatitis-B vaccination in children, J Kermanshah Univ Med Sci. 2012 ; 15(6):e78901.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 15 (6); e78901
Published Online: March 19, 2012
Article Type: Research Article
Received: April 11, 2011
Accepted: June 28, 2011

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Abstract

Background: Hepatitis- B infection is one of the infectious diseases that transmits via blood transfiosion, blood product, injection, mother to fetus and sexual contact. Protective anti hepatitis-B titer are observed in more than 90% of healthy children. The aim of this study was to evaluate seroconversion rates in children who received routine vaccination program.

Methods: A cross sectional study was designed. 196 children who received routine hepatitis-B vaccine (at birth, 2 and 6 months old) were selected. Anti hepatitis-B titer was measured using ELISA method in 6-7 years old children. Data was analyzed using chi-square and fisher exact tests.

Results: 69 % of all participants (98 boys and 98 girls) showed protective antibody titer (71.4% in girl and 67% in boys). There was no significant correlation between sex, weight and BMI and antibody response.

Conclusion: Seroconversion rate after hepatitis–B vaccination was lower than the semilar studies. The etiology of low seroconversion rate needs to do further study in Kermanshah. 

Keywords

hepatitis-B vaccination children

© 2012, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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