Low dose oral theophylline effects on HS-CRP in stable COPD patients

AUTHORS

Naseh Sigari 1 , * , Vahid Yousefinejad 2 , Jamal Seidi 3

1 Dept. of Internal Medicine, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

2 Dept. of Forensic Medicine, Tehran University of Medical Sciences, Tehran, Iran

3 Dept. of Operating Room, School of Para medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

How to Cite: Sigari N, Yousefinejad V, Seidi J. Low dose oral theophylline effects on HS-CRP in stable COPD patients, J Kermanshah Univ Med Sci. 2011 ; 15(4):e79285.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 15 (4); e79285
Published Online: November 19, 2011
Article Type: Research Article
Received: July 23, 2010
Accepted: December 14, 2010

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background: Low dose theophylline may have some anti-inflammatory effects on COPD patients. This study was conducted to determine the effect of oral low dose theophylline on serum CRP level in patients with stable COPD.

Methods: In this double blind randomized clinical trail study, 50 patients (25 in experimental and 25 in placebo group) were enrolled into the study by randomized blocking method. Serum HS-CRP using ELISA method was measured before and after the study. Data was analyzed using t-test and paired t-test.

Results: There was no significant difference in gender, age, smoking and spirometry variables before study between two groups. Serum HS-CRP level remained the same between two groups before and after the intervention.

Conclusion: More studies with large sample size needed to find anti-inflammatory effect of theophylline on macrophages and neutrophils and their derivative inflammatory materials in COPD patients.

Keywords

chronic obstructive pulmonary disease (COPD) HS-CRP theophylline

© 2011, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Fulltext

References

  • 1.

    The references of this article is available on PDF

  • COMMENTS

    LEAVE A COMMENT HERE: