The effects of propofol and thiopental on apgar score during cesarean section


Parisa Golfam 1 , * , Hasanali Karimpur 1 , Mitra Yari 1

1 Dept. of Anesthesiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

How to Cite: Golfam P , Karimpur H, Yari M. The effects of propofol and thiopental on apgar score during cesarean section, J Kermanshah Univ Med Sci. 2010 ; 14(1):e79537.


Journal of Kermanshah University of Medical Sciences: 14 (1); e79537
Published Online: June 19, 2010
Article Type: Research Article
Received: July 15, 2009
Accepted: November 24, 2009




Bachground: To induce anesthesia in cesarean, thiopental is often used, and propofol may be used as an alternative. Considering different effects and contradictions deriving from previous studies, this study aimed to investigate the effects of thiopental and propofol on apgar score.

Methods: A double blind clinical trial study was designed on pregnant women scheduled for elective cesarean. Patients were randomly divided in two groups of 30 subjects. The first group received propofol and the second group received thiopental to induce anesthesia. Heart rate, respiratory conditions, skin color of neonates and Apgar score of 1st and 5th minute were recorded. Blood pressure and heart rate of mothers was recorded five minutes before and after induction.

Results: The heart rate of neonates in the propofol group at the 30th second, was less than those in thiopental group. There was no statistical significant difference between respiratory status and the skin color of neonates at 30th second. In addition, there was no significant difference between the apgar score of 1st and 5th minute and the heart rate and blood pressure of mothers between two groups.

Conclusion: Since propofol had no adverse effect on mothers’ hemodynamics and the clinical status of neonates, it can be used as an alternative drug to induce anesthesia.


Cesarean Propofol Thiopental Neonate Apgar score

© 2010, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.


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