Efficacy of Hydroxy urea in Thalassemia intermedia

AUTHORS

MA Ehsaani 1 , * , AA HedaayatiAsl 1 , AR Baagheri 1

1 Iran

How to Cite: Ehsaani M, HedaayatiAsl A, Baagheri A. Efficacy of Hydroxy urea in Thalassemia intermedia, J Kermanshah Univ Med Sci. 2002 ; 6(3):e81014.

ARTICLE INFORMATION

Journal of Kermanshah University of Medical Sciences: 6 (3); e81014
Published Online: December 19, 2002
Article Type: Research Article
Received: August 12, 2002
Accepted: December 11, 2002

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Abstract

Introduction and Objectives: There is some controversy over the clinical efficacy of  Hydroxy urea in Thalassemia intermedia.

Materials and Methods: Therapeutic efficacy of  Hydroxy urea was evaluated in 16 patients with thalassemia intermedia, by measuring total hemoglobin and hemoglobin F levels before and 6months after treatment with Hydroxy urea (20mg/kg/day).

 Results: Mean increases in total hemoglobin and hemoglobin F levels 6mo after treatment with Hydroxy urea were 1.47±1.12gm/dl and 1.43±1.12 gm/dl, respectively. The most common mutation was found to be  IV S II-I betaglobin. 

 Discussion and Conclusions:  Use of Hydroxy urea in thalassemia intermedia is associated with increases in total hemoglobin and hemoglobin F levels.

Keywords

thalassemia intermedia Hydroxy urea IV S II-I mutation hemoglobin

© 2002, Journal of Kermanshah University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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